Cancer cells can often undergo changes in their DNA known as epigenetic modifications or DNA methylations, and these changes enable tumors to resist treatment. It’s thought that eliminating the epigenetic modifications may help mesothelioma patients to respond better to treatment and improve the prognosis of the patient.
Researchers are currently studying the effects of the drug 5-aza-dC which reduces DNA methylation to see if it can improve the effectiveness of anti-cancer drugs in mesothelioma patients. Scientists have discovered that although 5-aza-dC does not kill the mesothelioma cells it did reduce some of the processes which encourage cancer cells to grow such as interaction colony formation, cell migration, and invasiveness. Read more about this study here.
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