Pleural effusions occur when fluid builds up between the pleural layers. It can happen independently or as a symptom of advanced mesothelioma. Though people may live with it for years as the disease progresses, pain and irregular breathing may become severe. There are treatments to address pleural effusions, but a talc pleurodesis is the only way to assure that recurrence won’t happen. About 1.5 million cases of pleural effusion are diagnosed annually in the U.S. due to numerous causes.